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pentobarbital will lower the extent or impact of guanfacine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Intently. Strong or average CYP3A4 inducers appreciably lessen guanfacine plasma concentrations and elimination 50 %-life.pentobarbital will minimize the level or effect of elbasvir/grazoprevir by affec

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